Use this link for bookmarking this species for future reference. Other names: Isoindazole 1,2-Diazaindene 1H-Benzopyrazole 2-Azaindole Indazole Benzopyrazole Permanent link for this species. One lead compound, 29, was a potent and selective JNK3 inhibitor (IC50 = 0.005 μM) that had. Extensive structure activity relationship (SAR) studies utilizing various in vitro and in vivo assays led to potent and highly selective JNK3 inhibitors with good oral bioavailability and high brain penetration.
Chat now for more business.An indazole/aza-indazole scaffold was developed as a novel chemotype for JNK3 inhibition. Contact China Manufactory Shanghai United Chemicals Co.,Ltd. (Shrewsbury, MA, US) Burchat, Andrew (Shrewsbury, MA, US) Frank, Kristine E. These results demonstrate promising applications of phosphonate chain-end groups in the design of conjugated polymers for various purposes.Indazole derivatives reported in the literature proceed from benzene precursors in which the pyrazole moiety was generated by ring closure starting from isatins, phenylhydrazines or o-toluidines.14,15 To the best our knowledge, indazole-3-carboxilic acid has been synthesized conveniently for many years.16, 17 However, further modifications Ericsson, Anna M. More intriguing is the fact that high solubility and polarity of the resulting copolymers are induced via polar and bulky phosphonate chain-end groups, allowing for proper OFET operation using not only OTS-untreated Si/SiO 2 substrates but also an eco-friendly 2-methyltetrahydrofuran solution process.
In OFETs fabricated on n-octadecyltrimethoxysilane (OTS)-treated silicon (Si)/silicon dioxide (SiO 2) surfaces, the copolymers exhibit good hole transport with maximum hole mobility (μ h) of 1.46 × 10 –1 cm 2 V –1 s –1 in EH4P-TT, which is attributed to edge-on packing, fibrillar intercalating networks, and large crystalline π-stacking. It was found that introducing different counterpart comonomers into the main backbone alters the copolymers’ intrinsic properties, including absorption, frontier energy levels, molecular microstructure, and charge transport in OFETs. A series of highly soluble copolymers (EH4P-Th, EH4P-Se, EH4P-TT, and EH4P-BT) based on phosphonate chain-end functionalized diketopyrrolopyrrole monomer and four different counterpart comonomers with varied electron-donating strength and conjugation length have been synthesized, characterized, and used in p-channel organic field-effect transistors (OFETs).
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